Leukemia Cells Dangerous Diseases

Leukemia is a disease that is known by the proliferation of neoplasitik of hemopoietik organ cells, which occurs as a result of somatic cell mutation bakal (stem cell) that will form a clone of leukemia cells.
Diseases of the blood cancer (leukemia) was ranked as the highest cancer in children. However, the handling of cancer in children in Indonesia is still slow. That is why over 60% of children with cancer are treated medically had entered an advanced stage.

Leukemia is the proliferation of violence resulting in hemopoietik of abnormal cell clone and will undergo a transformation of leukemia cells, occurs on the abnormalities of cell differentiation and growth of lymphoid cells and mieloid.

Diagnosis of acute leukemia can be enforced from the examination of Hematology Hb, leukocytes, bones, i.e. acute leukemia cells based on the type classification of FAB.
Background

Leukemia is a disease that is known by the proliferation of neoplasitik of hemopoietik organ cells, which occurs as a result of somatic cell mutation bakal (stem cell) that will form a clone of leukemia cells.

Diseases of the blood cancer (leukemia) was ranked as the highest cancer in children. However, the handling of cancer in children in Indonesia is still slow. That is why over 60% of children with cancer are treated medically had entered an advanced stage.

Leukemia is the proliferation of violence resulting in hemopoietik of abnormal cell clone and will undergo a transformation of leukemia cells, occurs on the abnormalities of cell differentiation and growth of lymphoid cells and mieloid.

Diagnosis of acute leukemia can be enforced from the examination of Hematology Hb, leukocytes, bones, i.e. acute leukemia cells based on the type classification of FAB.

THE CONTENTS OF THE

Sitokimia coloring can be confirmed from acute leukemia cells are of lymphoid cells or mieloid. With the examination of immunopheno-typing diagnosis of acute leukemia can be known whether mieloid or lymphoid cells, even LLA can further do of didiferensiasi T cells or B cells. sitogenik Inspection will give instructions there/not the chromosome aberration.

Has done research on the eight subjects of acute leukemia cells, composed of four children, a teenager, two adults and a Seniors (three women and five men). Age range 4-82.

LMA is present on the four subjects, a child thirteen years LMA-M3, two adult LMA-M2 and a Geezer LMA-M2. ALL T cells on two subjects, a child and an adult. ALL B cells on two subjects, a child and an adult. LLA marked the existence of a T cell CD3, CD5, and CD7; ALL B cells marked lack of CD10, CD 19, CD20, CD22 and HLA-DR lMA marked presence of CD13 & CD33.

When immunophenotyping (on seven subjects) is used as the gold-standard for the diagnosis of acute leukemia cells, then the diagnosis based on examination of HB, leukocytes, platelets, calculate types and morphology of blood banks and specimens of apus or bone marrow sensitivitasnya is 71.4%. Tinting sitokimia consists of MPO, SBB, PAS, non-specific esterase and esterase-specific sensitivity of 100%.

Examination of sitogenetik in six subjects, all show chromosomal aberration. Trisomy 21 is present on three subjects (50%), there are two subjects with "abberrant expression", which is accompanied by the expression of mieloid cells on ALL B cells and B cells on the expression of ALL T cells.

There are two subjects with the chromosome aberration not found in the literature, namely 21, t (6; 11) to (q27; q23) on LMA-M3 and 17, 21, t (2; 6) to (q34; q26) on adolescents LLA B cells.

KOMPILIKASI INVOLVED IN CHRONIC LEUKEMIA CELLS

1. swelling of nodes in the neck, underarm spleen, stomach, or pubic.

2. the dreadful pain primarily under the sternum.

3. a sense of letihan and lesuan

4. Kehilang weight without a specific cause.

5. Fever

6. Receive hematoma with pleasure.

7. pain in the bones.

8. low levels of breathing (shortness of breath).

9. loses to eat.(loss of diet).

10. in property cases that mindset will cause death.

11. Petechiae (formation of red spots and sometimes shaped sharply below the surface of the skin caused by bleeding)

Symptoms:

headache, nausea, vomiting, decreased consciousness and seizures. "Other Symptoms include sudden unnoticed is pale, heat, there was bleeding, painful joints up to kidney failure. Heart experience swelling of the testes have enlarged as well. "

Prevention:

Conduct early detection of cancer to prevention. "Pencegahannya to consume vitamins A and C, the fruit and vegetables are rich in fiber."
How The Treatment
Treatment of acute blood cancer (acute leukaemia) according to the curative or palliative Mediayarti aim: curative Medicine include:
1. Siteroduksi with sitostatika drugs ranging from mild to sitosttika the combination of aggressive with membutukan "rescue" iduh cells from peripheral blood darh penderitah for rescue on the ablation of bone marrow.
2. allogeni blood stem cell transplant or autologus bone marrow, blood from the peripheral or the umbilical cord.
3. Suportip
Through a blood transfusion, giving vitamin B6, iron and 12, sufficient nutrition, antibiotic and anti-fungal if there is any indication. As for the treatment of chronic leukemia depending on the type and phase or stage where sufferers are found.
 
Source : http://id.wikipedia.org/wiki/Leukemia